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Name :
HMGA2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HMGA2 Rabbit Polyclonal antibody. Positive IF detected in A549 cells. Positive WB detected in NIH/3T3 cells. Positive IP detected in NIH/3T3 cells. Observed molecular weight by Western-blot: 18-20 kDa

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
BABL antibody; high mobility group AT hook 2 antibody; HMGA2 antibody; HMGI C antibody; HMGIC antibody; LIPO antibody; STQTL9 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HMGA2 recombinant protein (Accession Number: NM_003483). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IF: 1:10-1:100

Background :
HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors (18202751,19551524). HMGA2 is abundantly and ubiquitously expressed and plays a crucial role during embryonic development (18425117). HMGA2 promotes stem cell self-renewal and research studies have shown that decreased HMGA2 expression is associated with stem cell aging (19551524). Investigators have shown that expression levels of HMGA2 are very low in normal adult tissues, while either overexpression or rearrangement is associated with many types of cancer (20228781).This antibody specifically reacts with 18kd HMGA2 protein.

References :
Tan L, Wei X, Zheng L. Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML. Journal of cancer research and clinical oncology. 142(2):389-99. 2016.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel