Name :
HMGCR antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HMGCR Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human heart tissue.
Tested applications :
ELISA, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
HMG CoA reductase antibody; HMGCR antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HMGCR recombinant protein (Accession Number: NM_001130996). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200
Background :
HMGCR(3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family. This protein exists as a 97-kDa glycoprotein in the endoplasmic reticulum (ER) and is the rate-determining enzyme of the biosynthesis pathway(PMID:15830340).The ectopic expression of either full-length HMGCR or its novel splice variant promotes dysregulation of the MVA pathway. And the ectopic expression of cHMGCR-FL(60 kDa) and cHMGCR-D13(55 kDa) can be detected in HepG2 cells(PMID:20696928).This protein is also can exsit as a oligomer(PMID:20696928).
References :
Liu M, Xu L, Yin L. Potent effects of dioscin against obesity in mice. Scientific reports. 5:7973. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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