Name :
HN1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to HN1
Tested applications :
WB
Species reactivity :
Human
Alternative names :
JPT1 antibody; ARM2 antibody; HN1 antibody; HN1A antibody; Jupiter microtubule associated homolog 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human HN1 (NP_057269.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 ‘Ser-33’ phosphorylation and degradation through the suppression of the inhibitory ‘Ser-9’ phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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