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Name :
HNF1B antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HNF1B Rabbit Polyclonal antibody. Positive WB detected in L02 cells, Jurkat cells. Positive IHC detected in human pancreas cancer tissue, human liver cancer tissue. Observed molecular weight by Western-blot: 58-60kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
FJHN antibody; HNF 1 beta antibody; HNF 1B antibody; HNF1 homeobox B antibody; HNF1B antibody; HNF1beta antibody; HNF2 antibody; Homeoprotein LFB3 antibody; HPC11 antibody; LF B3 antibody; LFB3 antibody; MODY5 antibody; TCF 2 antibody; TCF2 antibody; Transcription factor 2 antibody; VHNF1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HNF1B recombinant protein (Accession Number: NM_000458). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
Hepatocyte nuclear factor-1-beta(HNF1B), or transcription factor-2(TCF2), is a member of the homeodomain-containing superfamily of transcription factors. Early expression of HNF1B(12533-1-AP) is seen in the kidney, liver, pancreas, thymus, lung, gut and genital tract. HNF1B can be a homodimer or a heterodimer with HNF1A. It’s a transcription factor, probably by binding to the inverted palindrome 5′-GTTAATNATTAAC-3′, and as a bookmarking factor that marks target genes for rapid transcriptional reactivation after mitosis. This is a rabbit polyclonal antibody raised against part chain of N-terminus of human HNF1B

References :
Shim JH, Lee HC, Han S, Kang HJ, Yu E, Lee SG. Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the Milan criteria in transplantable hepatocellular carcinoma: a retrospective analysis based on tissue microarrays. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 19(3):336-45. 2013. Min KW, Park MH, Hong SR. Clear cell carcinomas of the ovary: a multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 32(1):3-14. 2013. Lai CR, Hsu CY, Chen YJ, Yen MS, Chao KC, Li AF. Ovarian cancers arising from endometriosis: a microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2. Journal of the Chinese Medical Association : JCMA. 76(11):629-34. 2013. Kim JY, Park do Y, Kim GH, Jeon TY, Lauwers GY. Does clear cell carcinoma of stomach exist? Clinicopathological and prognostic significance of clear cell changes in gastric adenocarcinomas. Histopathology. 65(1):90-9. 2014. Seth A, Ye J, Yu N. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (Cambridge, England). 141(3):538-47. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel