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Name :
HNMT antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HNMT Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, mouse liver tissue. Positive IF detected in MCF-7 cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 33 kDa

Tested applications :

Species reactivity :
Human, Mouse, Rat; other species not tested.

Alternative names :
histamine N methyltransferase antibody; HMT antibody; HNMT antibody; HNMT S1 antibody; HNMT S2 antibody

Immunogen :
Human HNMT Recombinant protein (His tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HNMT recombinant protein (Accession Number: NM_006895). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100

Background :
HNMT, a histamine-metabolizing enzyme, inactivates histamine by N-methylation. It plays an important role in degrading histamine and in regulating the airway response to histamine. HNMT in human astrocytes play a role in the regulation of extraneuronal histamine concentration and the activities of histaminergic neurons.

References :
Yoshikawa T, Naganuma F, Iida T. Molecular mechanism of histamine clearance by primary human astrocytes. Glia. 61(6):905-16. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel