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Name :
HNRNPA2B1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HNRNPA2B1 Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, A549 cells, HeLa cells, Jurkat cells, K-562 cells, Raji cells. Positive IP detected in mouse liver tissue. Positive IHC detected in human lymphoma tissue, human cervical cancer tissue. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 36 kDa and 38 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
DKFZp779B0244 antibody; FLJ22720 antibody; hnRNP A2/B1 antibody; HNRNPA2 antibody; HNRNPA2B1 antibody; HNRNPB1 antibody; HNRPA2 antibody; HNRPA2B1 antibody; HNRPB1 antibody; RNPA2 antibody; SNRPB1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HNRNPA2B1 recombinant protein (Accession Number: BC000506). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:50-1:500

Background :
HnRNPA2B1 in one of heterogenous nuclear ribonucleoproteins (HnRNPs), which regulate the splicing and transportation of mRNA and participate in growth regulation and carcinogenesis. It has a role in packaging nascent mRNA, alternative splicing, tycoplamic RNA trafficking, translation and stabilization. Besides it may involve in telomere maintenance, cell proliferation and differentiation, and glucose transport. Gene HURNPA2B1 encode two protein, HNRNPA2 (38kd) and HNRNPB1 (36kd), by alternative splicing.

References :
Guo R, Li Y, Ning J, Sun D, Lin L, Liu X. HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells. PloS one. 8(4):e62729. 2013. Cho KI, Patil H, Senda E. Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. The Journal of biological chemistry. 289(8):4600-25. 2014. Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs. Human molecular genetics. 24(6):1513-27. 2015. Cho KI, Orry A, Park SE, Ferreira PA. Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. ACS chemical neuroscience. 6(8):1476-85. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel