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Name :
HNRNPD antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HNRNPD Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, Jurkat cells, mouse liver tissue. Positive IHC detected in human cervical cancer tissue, human placenta tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 38kd and 40kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
AUF1 antibody; AUF1A antibody; hnRNP D0 antibody; HNRNPD antibody; hnRNPD0 antibody; HNRPD antibody; P37 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HNRNPD recombinant protein (Accession Number: NM_002138). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200

Background :
The heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. HNRNPD, also known as AUF1, belongs to the family of AU-binding proteins (AU-BPs) that regulate the cellular half-lives of many mRNAs by directly interacting with an AU-rich element (ARE) located in their 3′ untranslated region [PMID:8578590,12704645]. AUF1 has four isoforms produced by alternative splicing of a single transcript: p37, p40, p42, and p45 (PMID:9521873).

References :
Neumann M, Valori CF, Ansorge O. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta neuropathologica. 124(5):705-16. 2012. Cooper-Knock J, Walsh MJ, Higginbottom A. Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. Brain : a journal of neurology. 137(Pt 7):2040-51. 2014. Chai F, Li HY, Wang W. Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection. Biochimica et biophysica acta. 1854(8):967-78. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel