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Name :
HOMER1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HOMER1 Rabbit Polyclonal antibody. Positive FC detected in HeLa cells. Positive IHC detected in mouse brain tissue, human ovary tumor tissue, human pancreas tissue. Positive WB detected in human brain tissue, human/mouse brain. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 46-48 kDa

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
HOMER antibody; Homer 1 antibody; homer homolog 1 (Drosophila) antibody; Homer protein homolog 1 antibody; HOMER1 antibody; HOMER1A antibody; HOMER1B antibody; HOMER1C antibody; SYN47 antibody; Ves 1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HOMER1 recombinant protein (Accession Number: NM_004272). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200

Background :
Human HOMER1, also named as SYN47, belongs to the Homer family. Human HOMER1 has some isoforms: HOMER1a, HOMER1b, HOMER1c, HOMER1e and HOMER1h. Mouse Homer1 also named as Vesl-1 and it has some isoforms: Vesl-1l, Vesl-1m, Vesl-1s, Homer1b, and Homer1d. HOMER1 is a postsynaptic density scaffolding protein. It is a neuronal immediate-early gene (IEG) that is enriched at excitatory synapses and binds mGluRs. In WB, the MW of HOMER1 is about 46-50kd, 40-43kd and 20-26kd.

References :
Su J, Tang Y, Zhou H, Liu L, Dong Q. Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c. Cellular signalling. 24(11):2205-15. 2012. Wu YY, Wang X, Tan L. Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components. Journal of Alzheimer’s disease : JAD. 37(3):515-27. 2013. Su JJ, Pan H, Zhou HG, Tang YP, Dong Q, Liu JR. Acid-sensing ion channels activation and hypoxia upregulate Homer1a expression. CNS neuroscience & therapeutics. 20(3):264-74. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel