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Name :
Anti-bFGF/FGF2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Rabbit monoclonal to bFGF/FGF2

Tested applications :

Species reactivity :
Human bFGF

Alternative names :
BFGF antibody; FGFB antibody; FGF-2 antibody; HBGF-2 antibody; Fgfb antibody; bFGF antibody; Fgf-2 antibody; bFGF antibody; BFGF antibody; DN-452A22.6 antibody; Fgf2 antibody; FGF2 antibody; Fgf-2 antibody; Fgfb antibody; FGFB antibody; HBGF-2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained from a rabbit immunized with purified, synthetic peptide corresponding to the N-terminus of the Human bFGF.

Clonality :

Formulation :
0.2 μm filtered solution in PBS with 5% trehalose

Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Applications :
WB: 0.5-1 μg/mlIHC-P: 0.5-2 μg/mL

Background :
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in remodeling damaged tissue, such as ulcer healing, vascular repair, traumatic brain injury (TBI). bFGF is a critical component of human embryonic stem cell culture medium. In addition, bFGF protein is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth. Thus, bFGF is regarded as a target for cancers chemopreventive and therapeutic strategies. bFGF/FGF2 Protein & Antibody Products

References :
Takayama S,et al. (2001) Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res. 80(12): 2075-9. Niu YJ, et al. (2004) Therapeutic effect of bFGF on retina ischemia-reperfusion injury. Chin Med J (Engl). 117(2): 252-7. Zhang Y,et al. (2004) Expression of aFGF, bFGF, and FGFR1 in ovarian epithelial neoplasm. Chin Med J (Engl). 117(4): 601-3.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel