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Name :
HOPX antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HOPX Rabbit Polyclonal antibody. Positive WB detected in mouse lung tissue, human placenta tissue, rat lung tissue. Positive IP detected in Mouse lung. Observed molecular weight by Western-blot: 8-12kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
CAMEO antibody; HOD antibody; Homeodomain only protein antibody; HOP antibody; HOP homeobox antibody; HOPX antibody; LAGY antibody; NECC1 antibody; OB1 antibody; Odd homeobox protein 1 antibody; SMAP31 antibody; TOTO antibody

Immunogen :
Human HOPX Recombinant protein (GST tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HOPX recombinant protein (Accession Number: NM_139212). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000

Background :
HOPX (Homeodomain-only protein) gene has various synonyms including HOD, HOP, OB1, LAGY and NECC1. The protein encoded by this gene is an unusual homeodomain protein that lacks certain conserved residues required for DNA binding. HOPX has diverse effects on cardiac growth. Manipulation of Hopx function in murine models is associated with cardiac hypertrophy, dilation and fibrosis. HOPX protein acts as an antagonist to the serum response factor (SRF), which regulates the opposing processes of cell proliferation and differentiation. Overexpression of HOPX causes cardiac hypertrophy. HOPX protein can inhibit SRF-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity.

References :
Cheung WK, Zhao M, Liu Z. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer cell. 23(6):725-38. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel