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Name :
Anti-BGN antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Rabbit Polyclonal to Human BGN

Tested applications :

Species reactivity :
Human Biglycan

Alternative names :
Biglycan antibody; BGN antibody; DSPG1 antibody; PG-S1 antibody; PGI antibody; SLRR1A antibody; biglycan proteoglycan antibody; bone/cartilage proteoglycan I antibody; dermatan sulphate proteoglycan I antibody; small antibody; Biglycan antibody; Bgn antibody; RP23-95K12.7 antibody; BG antibody; DSPG1 antibody; PG-S1 antibody; PGI antibody; SLRR1A antibody; bone/cartilage proteoglycan I antibody; PGI antibody; DSPG1 antibody; PG-S1 antibody; SLRR1A antibody; BG antibody; PGI antibody; DSPG1 antibody; PG-S1 antibody; SLRR1A antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human Biglycan, and purified by antigen affinity chromatography.

Clonality :

Formulation :
0.2 μm filtered solution in PBS

Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Applications :
IHC-P: 0.1-2 μg/mL

Background :
Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel