Name :
HPS5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HPS5 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, mouse spleen tissue. Positive IHC detected in human placenta tissue, human heart tissue, human lung tissue, human skin tissue. Positive IF detected in MCF-7 cells. Observed molecular weight by Western-blot: 135-141 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
AIBP63 antibody; Hermansky Pudlak syndrome 5 antibody; HPS5 antibody; KIAA1017 antibody; Ru2 antibody; Ruby eye protein 2 homolog antibody
Immunogen :
Human HPS5 Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HPS5 recombinant protein (Accession Number: NM_181508). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Hermansky-Pudlak syndrome 5 protein (HPS-5), also named Ruby-eye protien 2 homolog (Ru2), plays a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5.
References :
Cullinane AR, Curry JA, Carmona-Rivera C. A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9. American journal of human genetics. 88(6):778-87. 2011. Carmona-Rivera C, Golas G, Hess RA. Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent. The Journal of investigative dermatology. 131(12):2394-400. 2011. Cullinane AR, Curry JA, Golas G. A BLOC-1 mutation screen reveals a novel BLOC1S3 mutation in Hermansky-Pudlak Syndrome type 8. Pigment cell & melanoma research. 25(5):584-91. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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