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Name :
HPS5 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HPS5 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, mouse spleen tissue. Positive IHC detected in human placenta tissue, human heart tissue, human lung tissue, human skin tissue. Positive IF detected in MCF-7 cells. Observed molecular weight by Western-blot: 135-141 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
AIBP63 antibody; Hermansky Pudlak syndrome 5 antibody; HPS5 antibody; KIAA1017 antibody; Ru2 antibody; Ruby eye protein 2 homolog antibody

Immunogen :
Human HPS5 Recombinant protein (His tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HPS5 recombinant protein (Accession Number: NM_181508). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200

Background :
Hermansky-Pudlak syndrome 5 protein (HPS-5), also named Ruby-eye protien 2 homolog (Ru2), plays a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5.

References :
Cullinane AR, Curry JA, Carmona-Rivera C. A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9. American journal of human genetics. 88(6):778-87. 2011. Carmona-Rivera C, Golas G, Hess RA. Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent. The Journal of investigative dermatology. 131(12):2394-400. 2011. Cullinane AR, Curry JA, Golas G. A BLOC-1 mutation screen reveals a novel BLOC1S3 mutation in Hermansky-Pudlak Syndrome type 8. Pigment cell & melanoma research. 25(5):584-91. 2012.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel