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Name :
Anti-BID antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Rabbit Polyclonal to Mouse BID

Tested applications :

Species reactivity :
Mouse p22 BID

Alternative names :
2700049M22Rik antibody; AI875481 antibody; AU022477 antibody; Bid antibody; BID antibody; FP497 antibody; MGC15319 antibody; MGC42355 antibody; FP497 antibody; AI875481 antibody; AU022477 antibody; 2700049M22Rik antibody

Immunogen :
Mouse p22 BID (His & GST Tag) recombinant protein

Isotype :
Rabbit IgG

Preparation :
Produced in rabbits immunized with purified, recombinant Mouse p22 BID . p22 BID specific IgG was purified by Mouse p22 BID affinity chromatography.

Clonality :

Formulation :
0.2 μm filtered solution in PBS

Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Applications :
WB: 5-20 μg/mlELISA: 0.1-0.2 μg/mlThis antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Mouse p22 BID.IHC-P: 0.05-1 μg/mLIP: 1-4 μl/mg of lysate

Background :
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel