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Name :
HRSP12 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HRSP12 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Positive IHC detected in human liver cancer tissue. Observed molecular weight by Western-blot: 14.5kd

Tested applications :

Species reactivity :
Human, Rat; other species not tested.

Alternative names :
heat responsive protein 12 antibody; HRSP12 antibody; P14.5 antibody; PSP antibody; Ribonuclease UK114 antibody; UK114 antibody; UK114 antigen homolog antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HRSP12 recombinant protein (Accession Number: NM_005836). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
Ribonuclease UK114, also named HRSP12, is found predominantly in human adult kidney and liver and is responsible for inhibiting translation by cleaving mRNA. UK114 is mostly expressed in cytoplasm, but occasionally in nucleus in less differentiated cells. UK114 cleaves phosphodiester bonds only in single-stranded RNA. The levels of both the mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues, suggesting that ribonuclease UK114 may be an important biomarker for heptatic carcinoma. Current antibody catalog# 12930-1-AP is a rabbit polyclonal antibody raised from human full-length UK114.

References :
Dhawan L, Liu B, Pytlak A, Kulshrestha S, Blaxall BC, Taubman MB. Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells. Molecular and cellular biology. 32(18):3768-75. 2012.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel