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Name :
HSD17B2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HSD17B2 Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor tissue. Positive WB detected in human liver tissue, MCF7 cells. Observed molecular weight by Western-blot: 35-40 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
17 beta HSD 2 antibody; 17βHSD2 antibody; 20 alpha HSD antibody; E2DH antibody; EDH17B2 antibody; HSD17 antibody; HSD17B2 antibody; SDR9C2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HSD17B2 recombinant protein (Accession Number: NM_002153). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
HSD17B2(Estradiol 17-beta-dehydrogenase 2) is also named as 17-beta-HSD 2,20-alpha-HSD,EDH17B2 and belongs to the short-chain dehydrogenases/reductases (SDR) family.Based on the pivotal role of HSD17B2 gene product in the estrogen metabolism pathway, it may be considered as a putative candidate gene that could possibly explain a fraction of the remaining familial breast cancer risk and it is unlikely to play a role as a high penetrance gene in breast cancer predisposition(PMID:18372405).

References :
Aghajanova L, Hamilton A, Kwintkiewicz J, Vo KC, Giudice LC. Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biology of reproduction. 80(1):105-14. 2009. Shen Z, Saloniemi T, Rönnblad A, Järvensivu P, Pakarinen P, Poutanen M. Sex steroid-dependent and -independent action of hydroxysteroid (17beta) Dehydrogenase 2: evidence from transgenic female mice. Endocrinology. 150(11):4941-9. 2009. Wang J, Qin R, Ma Y. Differential gene expression in normal esophagus and Barrett’s esophagus. Journal of gastroenterology. 44(9):897-911. 2009. Chen N, Sun W, Deng X. Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC. Proteomics. 8(23-24):5108-18. 2008. Plante J, Simard M, Rantakari P. Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant. The Journal of steroid biochemistry and molecular biology. 117(4-5):139-45. 2009. Takagi K, Miki Y, Nagasaki S. Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment. Endocrine-related cancer. 17(2):415-30. 2010. Margarit L, Taylor A, Roberts MH. MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis. The Journal of clinical endocrinology and metabolism. 95(12):5320-9. 2010. Sasaki Y, Miki Y, Hirakawa H. Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma. Cancer science. 101(10):2286-92. 2010.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel