Name :
HSD17B2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HSD17B2 Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor tissue. Positive WB detected in human liver tissue, MCF7 cells. Observed molecular weight by Western-blot: 35-40 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
17 beta HSD 2 antibody; 17βHSD2 antibody; 20 alpha HSD antibody; E2DH antibody; EDH17B2 antibody; HSD17 antibody; HSD17B2 antibody; SDR9C2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HSD17B2 recombinant protein (Accession Number: NM_002153). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
HSD17B2(Estradiol 17-beta-dehydrogenase 2) is also named as 17-beta-HSD 2,20-alpha-HSD,EDH17B2 and belongs to the short-chain dehydrogenases/reductases (SDR) family.Based on the pivotal role of HSD17B2 gene product in the estrogen metabolism pathway, it may be considered as a putative candidate gene that could possibly explain a fraction of the remaining familial breast cancer risk and it is unlikely to play a role as a high penetrance gene in breast cancer predisposition(PMID:18372405).
References :
Aghajanova L, Hamilton A, Kwintkiewicz J, Vo KC, Giudice LC. Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biology of reproduction. 80(1):105-14. 2009. Shen Z, Saloniemi T, Rönnblad A, Järvensivu P, Pakarinen P, Poutanen M. Sex steroid-dependent and -independent action of hydroxysteroid (17beta) Dehydrogenase 2: evidence from transgenic female mice. Endocrinology. 150(11):4941-9. 2009. Wang J, Qin R, Ma Y. Differential gene expression in normal esophagus and Barrett’s esophagus. Journal of gastroenterology. 44(9):897-911. 2009. Chen N, Sun W, Deng X. Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC. Proteomics. 8(23-24):5108-18. 2008. Plante J, Simard M, Rantakari P. Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant. The Journal of steroid biochemistry and molecular biology. 117(4-5):139-45. 2009. Takagi K, Miki Y, Nagasaki S. Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment. Endocrine-related cancer. 17(2):415-30. 2010. Margarit L, Taylor A, Roberts MH. MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis. The Journal of clinical endocrinology and metabolism. 95(12):5320-9. 2010. Sasaki Y, Miki Y, Hirakawa H. Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma. Cancer science. 101(10):2286-92. 2010.
Related websites: https://www.medchemexpress.com/antibodies.html
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