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Name :
HSD17B4 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HSD17B4 Rabbit Polyclonal antibody. Positive IF detected in Hela cells. Positive IHC detected in human prostate cancer tissue, mouse heart tissue, mouse liver tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, mouse heart tissue, mouse liver tissue. Observed molecular weight by Western-blot: 79 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
17 beta HSD 4 antibody; D bifunctional protein antibody; DBP antibody; EDH17B4 antibody; HSD17B4 antibody; MFE 2 antibody; SDR8C1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HSD17B4 recombinant protein (Accession Number: NM_000414). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100

Background :
HSD17B4 (17-beta-hydroxysteroid dehydrogenase 4) is also named as Peroxisomal multifunctional enzyme type 2, D-bifuntional protein or multifunctional protein 2. It codes for a 80 kDa enzyme containing three distinct functional domains and is localized in peroxisomes. It is a bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids and catalyzing the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-brancked-chian fatty acids.

References :
Verheijden S, Bottelbergs A, Krysko O. Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation. Neurobiology of disease. 58:258-69. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel