Name :
IREB2 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to IREB2
Tested applications :
IF
Species reactivity :
Human
Alternative names :
IREB2 antibody; ACO3 antibody; IRP2 antibody; IRP2AD antibody; iron-responsive element-binding protein 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IREB2 (NP_004127.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
IF 1:20 – 1:50
Background :
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5′-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3′-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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