Name :
IRF5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IRF5 Mouse Monoclonal antibody. Positive IHC detected in human breast cancer tissue, human tonsillitis tissue. Positive IF detected in HepG2 cells. Positive WB detected in HeLa cells, HepG2 cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 63+110 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
interferon regulatory factor 5 antibody; IRF 5 antibody; IRF5 antibody; SLEB10 antibody
Immunogen :
Human IRF5 Recombinant protein (GST tag)
Isotype :
Mouse IgG2a
Preparation :
This antibody was obtained by immunization of IRF5 recombinant protein (Accession Number: XM_047420339). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
IRF5, also named as SLEB10, contians one IRF tryptophan pentad repeat DNA-binding domain and belongs to the IRF family. I t is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. It is activated by TLR7 or TLR8 signaling. Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) and systemic lupus erythematosus type 10 (SLEB10).
References :
Martin HJ, Lee JM, Walls D, Hayward SD. Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus. Journal of virology. 81(18):9748-58. 2007.
Related websites: https://www.medchemexpress.com/antibodies.html
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