Name :
IRS1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IRS1 Rabbit Polyclonal antibody. Positive IP detected in A549 cells. Positive WB detected in A549 cells, A431 cells, HEK-293 cells, PC-3 cells. Positive IF detected in A549 cells. Positive IHC detected in human breast cancer tissue, human liver tissue. Observed molecular weight by Western-blot: 160-185 kDa
Tested applications :
ELISA, WB, IHC, IP, IF
Species reactivity :
Human; other species not tested.
Alternative names :
HIRS 1 antibody; insulin receptor substrate 1 antibody; IRS 1 antibody; IRS1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IRS1 recombinant protein (Accession Number: NM_005544). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Insulin receptor substrate 1 (IRS1) was the first cloned and characterized member of the IRS family which are involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling. IRS1 is phosphorylated by insulin receptor tyrosine kinase and is involved in various cellular processes including DNA repair fidelity, transcriptional activity, and cell growth can support tumor development and progression. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. IRS1 has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS gel as a band of approximately 160-185 kDa.
References :
Liu M, Pan Q, Chen Y. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Scientific reports. 5:11219. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Anetumab
PRMT1 Antibody (YA686)
MSR1 Antibody: MSR1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 50 kDa, targeting to MSR1. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.
