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Name :
KCNK4 Polyclonal Antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Polyclonal antibody to KCNK4

Tested applications :
WB

Species reactivity :
Human

Alternative names :
KCNK4 antibody; K2p4.1 antibody; TRAAK antibody; TRAAK1 antibody; potassium channel subfamily K member 4 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-90 of human KCNK4 (NP_201567.1).

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.

Applications :
WB 1:500 – 1:2000

Background :
Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel