Name :
Anti-BTLA antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit Polyclonal to Mouse BTLA
Tested applications :
WB
Species reactivity :
Mouse BTLA / CD272
Alternative names :
A630002H24 antibody; B and T lymphocyte attenuator antibody; B and T lymphocyte attenuator antibody; B- and T-lymphocyte attenuator antibody; B- and T-lymphocyte attenuator antibody; B- and T-lymphocyte-associated protein antibody; B- and T-lymphocyte-associated protein antibody; BTLA1 antibody; CD272 antibody; A630002H24 antibody; BTLA1 antibody; CD272 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse BTLA / CD272, and purified by antigen affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 5-20 μg/ml
Background :
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).Immune CheckpointImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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