Name :
KDM4A antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KDM4A Rabbit Polyclonal antibody. Positive WB detected in NIH/3T3 cells, MCF-7 cells. Observed molecular weight by Western-blot: 55 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
JHDM3A antibody; JMJD2 antibody; JMJD2A antibody; KDM4A antibody; KIAA0677 antibody; lysine (K) demethylase 4A antibody; Lysine specific demethylase 4A antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KDM4A recombinant protein (Accession Number: XM_005271355). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000
Background :
KDM4A also named as JHDM3A, JMJD2, or KIAA0677 is a 1066 amino acid protein, which contains one JmjC domain, two Tudor domains and two PHD-type zinc fingers. KDM4A localizes in nucleus and belongs to the JHDM3 histone demethylase family. KDM4A is histone de-methylase that specifically demethylates Lys 9 and Lys 36 residues of Histone H3, thereby playing a central role in histone code. JMJD2A demethylation of lysine residues will generate formaldehyde and succinate. KDM4A also participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. JMJD2A is a ubiquitously expressed nuclear protein. KDM4A exists as two isoforms. The short isoform of KDM4A in which the N-terminal demethylase domains has been deleted. The molecular weight of short isoform is 55Da.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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