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Name :
LDHB antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
LDHB Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, DU 145 cells, PC-3 cells, rat brain tissue, rat liver tissue. Positive FC detected in HeLa cells. Positive IHC detected in human prostate tissue. Positive IF detected in Hela cells. Observed molecular weight by Western-blot: 35 kDa

Tested applications :
ELISA, WB, IHC, IF, FC, IP

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
lactate dehydrogenase B antibody; LDH B antibody; LDH H antibody; LDH heart subunit antibody; LDHB antibody; TRG 5 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of LDHB recombinant protein (Accession Number: NM_002300). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200

Background :
LDHB, also named as LDH-H and NY-REN-46, belongs to the LDH/MDH superfamily. And LDH family. It is an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway.It is glycolytic enzymes and it is positively regulated by mTOR.

References :
Sun Q, Chen X, Ma J. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America. 108(10):4129-34. 2011. Izquierdo-Álvarez A, Ramos E, Villanueva J. Differential redox proteomics allows identification of proteins reversibly oxidized at cysteine residues in endothelial cells in response to acute hypoxia. Journal of proteomics. 75(17):5449-62. 2012. Chen AP, Chu W, Gu YP, Cunningham CH, Cunnhingham CH. Probing early tumor response to radiation therapy using hyperpolarized Chung SH, Shen W, Gillies MC. Laser capture microdissection-directed profiling of glycolytic and mTOR pathways in areas of selectively ablated Müller cells in the murine retina. Investigative ophthalmology & visual science. 54(10):6578-85. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel