Name :
ACADVL antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ACADVL Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue. Positive IP detected in HeLa cells. Positive WB detected in mouse liver tissue, HeLa cells, mouse brain tissue. Observed molecular weight by Western-blot: 98 kDa,51 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ACAD6 antibody; ACADVL antibody; LCACD antibody; VLCAD antibody
Immunogen :
Human ACADVL Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ACADVL recombinant protein (Accession Number: NM_000018). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
VVery long-chain acyl-CoA dehydrogenase (VLCAD) is one of four flavoproteins which catalyze the initial step of the mitochondrial b-oxidation spiral. It belongs to the acyl-CoA dehydrogenase family and is a homodimer of a 71-kDa polypeptide which contains 2 mol of FAD/mol of enzyme. The molecular mass of the nondenatured trypsinized VLCAD is 98 kDa, by gel filtration chromatography, indicating that it is a homodimer of the 48 kDa(tryptic digest) polypeptide(PMID:9461620). Defects in ACADVL are the cause of acyl-CoA dehydrogenase very long chain deficiency (ACADVLD). It has 2 isoforms(70 kDa and 68 kDa ) produced by alternative splicing and a transit peptide. This antibody is speicifc to ACADVL.
References :
Huang D, Li T, Li X. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell reports. 8(6):1930-42. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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