Name :
GNB5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GNB5 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human brain tissue. Positive IP detected in rat brain tissue. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 39-42 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ37457 antibody; FLJ43714 antibody; GB5 antibody; Gbeta5 antibody; GNB5 antibody; Transducin beta chain 5 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GNB5 recombinant protein (Accession Number: BC011671). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins, which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit.
References :
Fuchs D, Metzig M, Bickeböller M, Brandel C, Roth W. The Gβ5 protein regulates sensitivity to TRAIL-induced cell death in colon carcinoma. Oncogene. 34(21):2753-63. 2015. Tracy CM, Kolesnikov AV, Blake DR. Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling. PloS one. 10(2):e0117129. 2015. Saba LM, Bennett B, Hoffman PL. A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology. 60(7-8):1269-80. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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