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Name :
GNE antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GNE Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human placenta tissue. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 79 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
DMRV antibody; GLCNE antibody; GNE antibody; IBM2 antibody; ManAc kinase antibody; Uae1 antibody; UDP GlcNAc 2 epimerase antibody

Immunogen :
Human GNE Recombinant protein (GST tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GNE recombinant protein (Accession Number: NM_005476). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
The bifunctional enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) is essential for early embryonic development and catalyzes the rate limiting step in sialic acid biosynthesis. It plays an important role in neuronal cell and brain development, and is strongly involved in cardiac tissue and skeletal muscle early survival and organization.. This protein has 5 isoforms produced by alternative splicing.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel