Name :
GPR132 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPR132 Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue. Positive IHC detected in human kidney tissue.
Tested applications :
ELISA, IHC, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
G protein coupled receptor 132 antibody; G2 accumulation protein antibody; G2A antibody; GPR132 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPR132 recombinant protein (Accession Number: NM_001278694). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200
Background :
GPR132, also known as G2A (G2 accumulation protein), belongs to the G-protein coupled receptor (GPCR) 1 family. GPR132 is a DNA damage and stress inducible GPCR that blocks cells in G2/M. It functions at the G2/M checkpoint to delay mitosis and may serve as a mechanism for T and B cells and other cell types to slow their proliferation and repair damaged DNA to ensure proper replication (PMID: 9770487). Lysophosphatidylcholine (LPC) is a high affinity ligand for GPR132 (PMID: 15653487).
References :
Fujita K, Sugiyama A, Otoshi K. Partial characterization of proapoptotic action of biliary deteriorated lipids on biliary epithelial cells in pancreaticobiliary diseases. Journal of hepato-biliary-pancreatic sciences. 21(3):212-8. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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