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Name :
GPR137 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GPR137 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 50kd

Tested applications :
ELISA, WB, IHC

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
C11orf4 antibody; G protein coupled receptor 137 antibody; GPR137 antibody; GPR137A antibody; TM7SF1L1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GPR137 recombinant protein (Accession Number: NM_001378082). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
G protein-coupled receptors (GPRs) are highly related to oncogenesis and cancer metastasis. G protein-coupled receptor 137 (GPR137) was initially reported as a novel orphan GPR about 10 years ago. GPR137 is ubiquitously expressed in the central nervous system (CNS), mainly in the hippocampus (PMID: 22025619). GPR137 is involved in the progression of human glioma, suggesting GPR137 as a potential oncogene of glioma cells (PMID: 24870220). Recent study shows that GPR137 plays an important role in colon cancer cell proliferation (PMID: 25301753).

References :
Du Y, Bi W, Zhang F, Wu W, Xia S, Liu H. G-protein-coupled receptor 137 accelerates proliferation of urinary bladder cancer cells in vitro. Biotechnology and applied biochemistry. 62(6):855-60. 2015. Wang Z, Zhang H, Wang J, Yang Y, Wu Q. RNA interference-mediated silencing of G protein-coupled receptor 137 inhibits human gastric cancer cell growth. Molecular medicine reports. 11(4):2578-84. 2015. Zong G, Wang H, Li J, Xie Y, Bian E, Zhao B. Inhibition of GPR137 expression reduces the proliferation and colony formation of malignant glioma cells. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 35(11):1707-14. 2014. Cui X, Liu Y, Wang B. Knockdown of GPR137 by RNAi inhibits pancreatic cancer cell growth and induces apoptosis. Biotechnology and applied biochemistry. 62(6):861-7. 2015. Shao X, Liu Y, Huang H. Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines. Cell biology international. 39(4):418-26. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel