Name :
GPR137 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPR137 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 50kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
C11orf4 antibody; G protein coupled receptor 137 antibody; GPR137 antibody; GPR137A antibody; TM7SF1L1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPR137 recombinant protein (Accession Number: NM_001378082). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
G protein-coupled receptors (GPRs) are highly related to oncogenesis and cancer metastasis. G protein-coupled receptor 137 (GPR137) was initially reported as a novel orphan GPR about 10 years ago. GPR137 is ubiquitously expressed in the central nervous system (CNS), mainly in the hippocampus (PMID: 22025619). GPR137 is involved in the progression of human glioma, suggesting GPR137 as a potential oncogene of glioma cells (PMID: 24870220). Recent study shows that GPR137 plays an important role in colon cancer cell proliferation (PMID: 25301753).
References :
Du Y, Bi W, Zhang F, Wu W, Xia S, Liu H. G-protein-coupled receptor 137 accelerates proliferation of urinary bladder cancer cells in vitro. Biotechnology and applied biochemistry. 62(6):855-60. 2015. Wang Z, Zhang H, Wang J, Yang Y, Wu Q. RNA interference-mediated silencing of G protein-coupled receptor 137 inhibits human gastric cancer cell growth. Molecular medicine reports. 11(4):2578-84. 2015. Zong G, Wang H, Li J, Xie Y, Bian E, Zhao B. Inhibition of GPR137 expression reduces the proliferation and colony formation of malignant glioma cells. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 35(11):1707-14. 2014. Cui X, Liu Y, Wang B. Knockdown of GPR137 by RNAi inhibits pancreatic cancer cell growth and induces apoptosis. Biotechnology and applied biochemistry. 62(6):861-7. 2015. Shao X, Liu Y, Huang H. Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines. Cell biology international. 39(4):418-26. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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