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Name :
GRB2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GRB2 Rabbit Polyclonal antibody. Positive IF detected in HEK-293 cells. Positive WB detected in HEK-293 cells, A431 cells, C2C12 cells, rat brain tissue, rat spleen tissue. Observed molecular weight by Western-blot: 25-28kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
Adapter protein GRB2 antibody; ASH antibody; EGFRBP GRB2 antibody; GRB2 antibody; Grb3 3 antibody; MST084 antibody; MSTP084 antibody; Protein Ash antibody; SH2/SH3 adapter GRB2 antibody

Immunogen :
Human GRB2 Recombinant protein (GST tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GRB2 recombinant protein (Accession Number: NM_002086). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IF: 1:10-1:100

Background :
GRB2 (growth factor receptor-bound protein 2) binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. N-SH3 domain of Grb2 was involved in the protein vesicular localization including amyloid-β protein precursor (AβPP). Involvement of GRB2 in Ras-signaling pathway has been reported, recent finding show that GRB2 may also play a complex role in T and B-cell antigen receptor signaling.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel