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Name :
GSPT2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GSPT2 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in MCF7 cells, NIH/3T3 cells. Observed molecular weight by Western-blot: 69kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
eRF3b antibody; FLJ10441 antibody; G1 to S phase transition 2 antibody; GSPT2 antibody; GST2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GSPT2 recombinant protein (Accession Number: NM_018094). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200

Background :
GSPT2, also named as Eukaryotic peptide chain release factor GTP-binding subunit ERF3B or G1 to S phase transition protein 2 homolog, is a 628 amino acid protein, which belongs to the GTP-binding elongation factor family. ERF3 subfamily. GSPT2 localizes in the cytoplasm and is highly expressed in IUCC stage II colorectal cancer (CRC). GSPT2 is involved in translation termination in response to the termination codons UAA, UAG and UGA and may play a role as a potent stimulator of the release factor activity of ETF1. It may play a role in cell cycle progression.

References :
Huang KL, Chadee AB, Chen CY, Zhang Y, Shyu AB. Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate. RNA (New York, N.Y.). 19(3):295-305. 2013. Su H, Meng S, Lu Y. Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. Molecular cell. 43(1):97-109. 2011.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel