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Name :
GUCY2F antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GUCY2F Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue. Positive IHC detected in human heart tissue. Observed molecular weight by Western-blot: 125 kDa

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
CYGF antibody; GC F antibody; guanylate cyclase 2F antibody; retinal antibody; Guanylate cyclase F antibody; GUC2DL antibody; GUC2F antibody; GUCY2F antibody; RETGC 2 antibody; RETGC2 antibody; Retinal guanylyl cyclase 2 antibody; ROS GC2 antibody

Immunogen :
Human GUCY2F Recombinant protein (His tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GUCY2F recombinant protein (Accession Number: NM_001522). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
GUCY2F(Guanylate cyclase 2F, retinal) is also named as GUC2F, RETGC2 and belongs to the adenylyl cyclase class-4/guanylyl cyclase family. GUCY2F may play a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. By in situ hybridization, mRNA encoding GUCY2F is found only in the outer nuclear layer and inner segments of photoreceptor cells. By using synthetic peptide antiserum specific for each RetGC subtype, RetGC-2(GUCY2F) can be distinguished from RetGC-1 as a slightly smaller protein in immunoblots of bovine rod outer segments.(PMID:7777544).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel