Name :
Anti-Bcl10 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Bcl10 Rabbit monoclonal antibody
Tested applications :
WB, ICC/IF, IP
Species reactivity :
Human
Alternative names :
Immunogen :
Isotype :
IgG
Preparation :
Antigen: A synthetic peptide of human Bcl10
Clonality :
Monoclonal
Formulation :
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/1000ICC/IF: 1/50IP: 1/20
Background :
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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