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Name :
GYS1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GYS1 Rabbit Polyclonal antibody. Positive FC detected in HepG2 cells. Positive IHC detected in human prostate cancer tissue, human skeletal muscle tissue. Positive IF detected in HepG2 cells. Positive IP detected in mouse skeletal muscle tissue. Positive WB detected in K-562 cells, HeLa cells. Observed molecular weight by Western-blot: 84 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
glycogen synthase 1 (muscle) antibody; GSY antibody; GYS antibody; GYS1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GYS1 recombinant protein (Accession Number: NM_002103). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:1000IHC: 1:20-1:200IF: 1:20-1:200

Background :
GYS1(Glycogen [starch] synthase, muscle) is the the rate limiting enzyme of the insulin-induced glycogenesis, transferring glucose units from UDP-Glc to a glycogen primer. It catalyzes the linear addition of glucose residues to the branching structure of glycogen, providing a convenient store of glucose for times of metabolic need. This protein has 2 isoforms produced by alternative splicing.

References :
Hall AM, Brunt EM, Chen Z. Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. Journal of lipid research. 51(3):554-63. 2010. Harris LA, Shew TM, Skinner JR, Wolins NE. A single centrifugation method for isolating fat droplets from cells and tissues. Journal of lipid research. 53(5):1021-5. 2012. Zhu H, Sun A, Zou Y, Ge J. Inducible metabolic adaptation promotes mesenchymal stem cell therapy for ischemia: a hypoxia-induced and glycogen-based energy prestorage strategy. Arteriosclerosis, thrombosis, and vascular biology. 34(4):870-6. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel