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Name :
Hemoglobin epsilon-Specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Hemoglobin epsilon-Specific Mouse Monoclonal antibody. Positive FC detected in K-562 cells. Positive WB detected in K-562 cells. Observed molecular weight by Western-blot: 16 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
Epsilon globin antibody; HBE antibody; Hemoglobin epsilon antibody; Hemoglobin epsilon chain antibody; Hemoglobin subunit epsilon antibody; hemoglobin antibody; epsilon 1 antibody

Immunogen :

Isotype :
Mouse IgG1

Preparation :
This antibody was obtained by immunization of recombinant protein (Accession Number: NM_005330). Purification method: Protein G purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000

Background :
The hemoglobin molecule is a tetramer consisting of two α-globin-like polypeptide chains and two β-globin-like chains. The human hemoglobin genes are expressed in a tightly developmentally controlled fashion.ε-globin (HBE1) is the predominantly expressed gene during the embryonic stage. The epsilon hemoglobin chain seems to be the best marker for fetal nucleated red blood cells (NRBCs). Anti-HBE1 may be used to label and isolate fetal cells from maternal blood and can be useful in prenatal diagnosis. This antibody specifically recognizes the HBE1 and doesn’t cross-react with other globin chains.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel