Name :
Anti-Beclin 1 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Beclin 1 Rabbit polyclonal antibody
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
ATG6; VPS30; beclin1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant protein of human Beclin 1
Clonality :
Polyclonal
Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at -20°C. Stable for 12 months from date of receipt.
Applications :
WB: 1/1000
Background :
Swiss-Prot Acc.Q14457.Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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