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Name :
Hexokinase 2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Hexokinase 2 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in Jurkat cells, A431 cells, HeLa cells, K-562 cells, MCF7 cells. Positive IHC detected in human skeletal muscle tissue. Observed molecular weight by Western-blot: 102kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
DKFZp686M1669 antibody; Hexokinase 2 antibody; Hexokinase type II antibody; HK II antibody; HK2 antibody; HKII antibody; HXK2 antibody; Muscle form hexokinase antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Hexokinase 2 recombinant protein (Accession Number: NM_000189). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200

Background :
HK2 represents hexokinase 2

References :
Yan S, Zhang Q, Zhong X. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes. 63(9):2911-23. 2014. Ma X, Li C, Sun L. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature communications. 5:5212. 2014. Sun L, Song L, Wan Q. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell research. 25(4):429-44. 2015. Zhuo B, Li Y, Li Z. PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma. Biochemical and biophysical research communications. 464(2):401-6. 2015. Zhou P, Chen WG, Li XW. MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer. American journal of cancer research. 5(6):2056-63. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel