Name :
HEY1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HEY1 Rabbit Polyclonal antibody. Positive IP detected in mouse kidney tissue. Positive WB detected in DU 145 cells, mouse testis tissue. Positive IHC detected in human brain tissue, human kidney tissue. Observed molecular weight by Western-blot: 32-34 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
BHLHb31 antibody; CHF 2 antibody; CHF2 antibody; HERP2 antibody; HESR 1 antibody; HESR1 antibody; HEY1 antibody; hHRT1 antibody; HRT 1 antibody; HRT1 antibody; OAF1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HEY1 recombinant protein (Accession Number: NM_012258). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
Hairy/enhancer of split-related proteins are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. And HEY1 is one of such protein. It is the direct downstream effector of Notch signaling which may be required for cardiovascular development. It preferentially bind to the canonical E box sequence 5′-CACGTG-3′ and acts as a transcriptional repressor. HEY1 is a 33kDa protein and forms dimer by self-associating.
References :
Jiang H, Cheng XW, Shi GP. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nature communications. 5:3838. 2014. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. 2B.06: EPIGALLOCATECHIN-3-GALLATE ATTENUATES URIC ACID-INDUCED INFLAMMATORY RESPONSES AND OXIDATIVE STRESS BY MODULATING NOTCH PATHWAY. Journal of hypertension. 33 Suppl 1:e23. 2015. Kang H, Jeong JY, Song JY. Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells. Molecular carcinogenesis. 2015. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway. Oxidative medicine and cellular longevity. 2015:214836. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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