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Name :
HEY1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HEY1 Rabbit Polyclonal antibody. Positive IP detected in mouse kidney tissue. Positive WB detected in DU 145 cells, mouse testis tissue. Positive IHC detected in human brain tissue, human kidney tissue. Observed molecular weight by Western-blot: 32-34 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
BHLHb31 antibody; CHF 2 antibody; CHF2 antibody; HERP2 antibody; HESR 1 antibody; HESR1 antibody; HEY1 antibody; hHRT1 antibody; HRT 1 antibody; HRT1 antibody; OAF1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HEY1 recombinant protein (Accession Number: NM_012258). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200

Background :
Hairy/enhancer of split-related proteins are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. And HEY1 is one of such protein. It is the direct downstream effector of Notch signaling which may be required for cardiovascular development. It preferentially bind to the canonical E box sequence 5′-CACGTG-3′ and acts as a transcriptional repressor. HEY1 is a 33kDa protein and forms dimer by self-associating.

References :
Jiang H, Cheng XW, Shi GP. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nature communications. 5:3838. 2014. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. 2B.06: EPIGALLOCATECHIN-3-GALLATE ATTENUATES URIC ACID-INDUCED INFLAMMATORY RESPONSES AND OXIDATIVE STRESS BY MODULATING NOTCH PATHWAY. Journal of hypertension. 33 Suppl 1:e23. 2015. Kang H, Jeong JY, Song JY. Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells. Molecular carcinogenesis. 2015. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway. Oxidative medicine and cellular longevity. 2015:214836. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel