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Name :
HEY2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HEY2 Rabbit Polyclonal antibody. Positive IP detected in mouse heart tissue. Positive WB detected in K-562 cells, 4T1 cells, human heart tissue, MCF-7 cells, mouse heart tissue. Positive IHC detected in human prostate cancer tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 34-36 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
bHLHb32 antibody; CHF1 antibody; GRIDLOCK antibody; GRL antibody; hCHF1 antibody; HERP antibody; HERP1 antibody; HESR 2 antibody; HESR2 antibody; HEY2 antibody; hHRT2 antibody; HRT 2 antibody; HRT2 antibody; Protein gridlOCk homolog antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HEY2 recombinant protein (Accession Number: NM_012259). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200

Background :
Hairy/enhancer of split-related proteins, such as HEY2, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. HEY2 is similarly expressed in the somites whereas it shows a complementary expression in the heart, the craniofacial region and the nervous system. This antibody is a rabbit polyclonal antibody raised against full length of human HEY2

References :
Fujitani M, Cancino GI, Dugani CB. TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Current biology : CB. 20(22):2058-65. 2010. Morioka T, Sakabe M, Ioka T. An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis (New York, N.Y. : 2000). 52(11):897-906. 2014. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. 2B.06: EPIGALLOCATECHIN-3-GALLATE ATTENUATES URIC ACID-INDUCED INFLAMMATORY RESPONSES AND OXIDATIVE STRESS BY MODULATING NOTCH PATHWAY. Journal of hypertension. 33 Suppl 1:e23. 2015. Kang H, Jeong JY, Song JY. Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells. Molecular carcinogenesis. 2015. Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway. Oxidative medicine and cellular longevity. 2015:214836. 2015. Fujita M, Sakabe M, Ioka T. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mechanisms of development. 2015. Mu X, Liao X, Chen X. DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms. Journal of hazardous materials. 298:232-40. 2015. Raafat A, Lawson S, Bargo S. Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis. Oncogene. 28(2):219-30. 2009.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel