Name :
HEY1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to HEY1
Tested applications :
WB
Species reactivity :
Human
Alternative names :
HEY1 antibody; BHLHb31 antibody; CHF2 antibody; HERP2 antibody; HESR1 antibody; HRT-1 antibody; OAF1 antibody; hHRT1 antibody; hairy/enhancer-of-split related with YRPW motif protein 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HEY1 (NP_001269780.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Transcriptional repressor which binds preferentially to the canonical E box sequence 5′-CACGTG-3′. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Involved in the regulation of liver cancer cells self-renewal.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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