Name :
HGS antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HGS Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, HEK-293 cells, K-562 cells. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 110-115 kDa
Tested applications :
ELISA, WB, IP, IF, IHC
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
HGS antibody; HRS antibody; Protein pp110 antibody; ZFYVE8 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HGS recombinant protein (Accession Number: NM_004712). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:500-1:5000IHC: 1:50-1:500IF: 1:10-1:100
Background :
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS, synonyms: HRS, ZFYVE8) is a 110 to 115-kDa zinc finger phosphotyrosine protein inducible by stimulation with interleukin 2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as hepatocyte growth factor (HGF), and is associated with signal-transducing adaptor molecule (STAM). HGS suppresses DNA synthesis upon stimulation with IL-2 and GM-CSF, counteracting the function of STAM which is critical for cell growth signaling mediated by the cytokines. HGS also interacts with the neurofibromatosis 2 tumor suppressor protein schwannomin/merlin. The growth suppression activity of schwannomin/merlin requires HGS and the binding of schwannomin/merlin to HGS facilitates its ability to function as a tumor suppressor, probably by inhibiting STAT activation.
References :
Holleman J, Marchese A. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Molecular biology of the cell. 25(12):1892-904. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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