Name :
HIF2a Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to HIF2a
Tested applications :
WB, IF
Species reactivity :
Human, Mouse
Alternative names :
EPAS1 antibody; ECYT4 antibody; HIF2A antibody; HLF antibody; MOP2 antibody; PASD2 antibody; bHLHe73 antibody; endothelial PAS domain protein 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 588-870 of human HIF2a (NP_001421.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000IF 1:50 – 1:100
Background :
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5′-TACGTG-3′ within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Phospho-AKT1(Ser473) Antibody
Mosunetuzumab
Phospho-JNK (Thr183) Antibody: Phospho-JNK (Thr183) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 48 kDa, targeting to Phospho-JNK (Thr183). It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.
