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Name :
HIGD1A antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HIGD1A Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HepG2 cells, rat brain tissue, rat kidney tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 10kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
DKFZp564K247 antibody; HIG1 antibody; HIG1 domain family member 1A antibody; HIGD1A antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HIGD1A recombinant protein (Accession Number: NM_001099669). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100

Background :
HIG1 domain family member 1A (HIGD1A) is a proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (22342701). It is induced by hypoxia induction.This antibody is a rabbit polyclonal antibody raised against a full-length human HIGD1A protein.

References :
Hayashi T, Asano Y, Shintani Y. Higd1a is a positive regulator of cytochrome c oxidase. Proceedings of the National Academy of Sciences of the United States of America. 112(5):1553-8. 2015. Ameri K, Rajah AM, Nguyen V. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PloS one. 8(4):e62758. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel