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Name :
HIP1-Specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HIP1-Specific Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells, HEK-293 cells, mouse colon tissue. Positive IP detected in HEK-293 cells. Positive IHC detected in human brain tissue, human colon cancer tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 116 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
HIP 1 antibody; HIP I antibody; HIP1 antibody; ILWEQ antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_005338). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200

Background :
HIP1 Belongs to the SLA2 family. HIP1 plays a role in clathrin-mediated endocytosis and trafficking. It is involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It enhances androgen receptor (AR)-mediated transcription. HIP1 may act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. It binds 3-phosphoinositides (via ENTH domain). HIP1 may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1 plays a functional role in the cell filament networks. It is required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). The antibody is specific to HIP1.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel