Name :
HIP1-Specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HIP1-Specific Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells, HEK-293 cells, mouse colon tissue. Positive IP detected in HEK-293 cells. Positive IHC detected in human brain tissue, human colon cancer tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 116 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
HIP 1 antibody; HIP I antibody; HIP1 antibody; ILWEQ antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_005338). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200
Background :
HIP1 Belongs to the SLA2 family. HIP1 plays a role in clathrin-mediated endocytosis and trafficking. It is involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It enhances androgen receptor (AR)-mediated transcription. HIP1 may act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. It binds 3-phosphoinositides (via ENTH domain). HIP1 may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1 plays a functional role in the cell filament networks. It is required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). The antibody is specific to HIP1.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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