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Name :
HIP14; ZDHHC17 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HIP14; ZDHHC17 Rabbit Polyclonal antibody. Positive IHC detected in human testis. Positive WB detected in Raji cells, human kidney tissue. Observed molecular weight by Western-blot: 70kd

Tested applications :

Species reactivity :
human, mouse, rat; other species not tested.

Alternative names :
ZDHHC17 antibody; HIP14 antibody; Palmitoyltransferase ZDHHC17 antibody; HIP 14 antibody; DHHC 17 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HIP14; ZDHHC17 recombinant protein (Accession Number: NM_015336). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. ZDHHC17 gene encodes palmitoyl transferase huntingtin interacting protein (HIP14) which regulates palmitoylation and distribution of hungtingtin. The latter is implicated in the formation of inclusion bodies and enhanced neuronal toxicity. HIP14 was also shown to control neurotransmitter release.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel