Name :
Histone H3.3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Histone H3.3 Rabbit Polyclonal antibody. Positive WB detected in A431 cells, HEK-293 cells, HeLa cells, mouse kidney tissue, mouse lung tissue, mouse thymus tissue. Positive IF detected in A431 cells. Observed molecular weight by Western-blot: 15-17 kDa
Tested applications :
ELISA, WB, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
H3 histone antibody; family 3A antibody; H3.3A antibody; H3.3B antibody; H3F3 antibody; H3F3A antibody; H3F3B antibody; Histone H3.3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Histone H3.3 recombinant protein (Accession Number: NM_001379046). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IF: 1:50-1:500
Background :
Histones are the basic nuclear proteins responsible for the nucleosome structure of the chromosomal fiber. Five classes of histone genes have been reported, some of which are expressed only during S phase, while others are replication independent. The latter are referred to as replacement histones and are expressed in quiescent or terminally differentiated cells. [PMID: 8586426] Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. H3F3A is one replacement histone [PMID:16258499].
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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