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Name :
HLA class I (HLA-B) antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HLA class I (HLA-B) Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human spleen tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue. Positive IP detected in HepG2 cells. Positive WB detected in Jurkat cells, HeLa cells, HepG2 cells, MCF7 cells. Observed molecular weight by Western-blot: 40-45kd

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
HLA B antibody; HLA B 7301 antibody; HLA B73 antibody; HLAB antibody; HLA-B antibody; HLAC antibody; MHC class I antigen B*7 antibody; SPDA1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HLA class I (HLA-B) recombinant protein (Accession Number: BC013187). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:1000-1:10000IHC: 1:20-1:200IF: 1:20-1:200

Background :
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and β2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens to the immune system. (PMID: 667938; 3375250)

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel