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Name :
HMGN1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HMGN1 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HeLa cells. Positive IF detected in HepG2. Observed molecular weight by Western-blot: 17kd

Tested applications :

Species reactivity :
human, mouse, rat; other species not tested.

Alternative names :
HMGN1 antibody; FLJ27265 antibody; HMG14 antibody; FLJ31471 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HMGN1 recombinant protein (Accession Number: NM_004965). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IF: 1:10-1:100

Background :
HMGN1 (high-mobility group nucleosome-binding protein 1) is a member of the HMG superfamily of nonhistone chromatin-binding proteins, which which regulate chromatin structure and gene transcription. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. It may participate in the process which maintains transcribable genes in an unique chromatin conformation, and inhibit the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 expressed abundantly

References :
Wei F, Yang D, Tewary P. The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant. Cancer research. 74(21):5989-98. 2014. Yang D, Postnikov YV, Li Y. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. The Journal of experimental medicine. 209(1):157-71. 2012.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel