Name :
HMGN2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HMGN2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HeLa cells, HepG2 cells, HL-60 cells, K-562 cells. Positive IHC detected in human prostate cancer tissue, human cervical cancer tissue. Observed molecular weight by Western-blot: 18-20 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
HMG17 antibody; HMGN2 antibody
Immunogen :
Human HMGN2 Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HMGN2 recombinant protein (Accession Number: NM_005517). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
HMGN2 is a highly conserved nucleosomal protein which may involve in unfolding higher-order chromatin structure and facilitating the transcriptional activation of mammalian genes. It is the most abundant, ubiquitous and evolutionarily conserved nonhistione proteins found in the nuclei of higher eukaryotes. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer.
References :
Su L, Hu A, Luo Y, Zhou W, Zhang P, Feng Y. HMGN2, a new anti-tumor effector molecule of CD8⁺ T cells. Molecular cancer. 13:178. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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