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Name :
HMGN2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HMGN2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HeLa cells, HepG2 cells, HL-60 cells, K-562 cells. Positive IHC detected in human prostate cancer tissue, human cervical cancer tissue. Observed molecular weight by Western-blot: 18-20 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
HMG17 antibody; HMGN2 antibody

Immunogen :
Human HMGN2 Recombinant protein (GST tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HMGN2 recombinant protein (Accession Number: NM_005517). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
HMGN2 is a highly conserved nucleosomal protein which may involve in unfolding higher-order chromatin structure and facilitating the transcriptional activation of mammalian genes. It is the most abundant, ubiquitous and evolutionarily conserved nonhistione proteins found in the nuclei of higher eukaryotes. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer.

References :
Su L, Hu A, Luo Y, Zhou W, Zhang P, Feng Y. HMGN2, a new anti-tumor effector molecule of CD8⁺ T cells. Molecular cancer. 13:178. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel