Name :
HSD11B1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HSD11B1 Rabbit Polyclonal antibody. Positive WB detected in L02 cells, Jurkat cells, mouse liver tissue. Observed molecular weight by Western-blot: 65-70 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
11 beta HSD1 antibody; 11 DH antibody; HDL antibody; HSD11 antibody; HSD11B antibody; HSD11B1 antibody; HSD11L antibody; SDR26C1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HSD11B1 recombinant protein (Accession Number: NM_005525). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000
Background :
HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed(PMID:18209879).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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