Name :
IRSp53 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IRSp53 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, human brain tissue, rat brain tissue. Observed molecular weight by Western-blot: 53 kDa
Tested applications :
ELISA, IHC, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
BAI assOCiated protein 2 antibody; BAI1 assOCiated protein 2 antibody; BAIAP2 antibody; BAP2 antibody; Fas ligand assOCiated factor 3 antibody; FLAF3 antibody; Insulin receptor substrate p53 antibody; IRS 58 antibody; IRSp53 antibody; IRSp53/58 antibody; Protein BAP2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IRSp53 recombinant protein (Accession Number: NM_001385140). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
IRSp53 (also known as BAIAP2) is a multi-domain adaptor protein that originally identified as a 58/53-kDa substrate of insulin-receptor kinase in the hamster (PMID: 10332026). As a BAI1-binding protein, IRSp53 plays an important role in linking between membrane and cytoskeleton in the process of neuronal growth (PMID: 10343108). IRSp53 is necessary for Cdc42-mediated reorganization of the actin cytoskeleton and for Rac1-mediated membrane ruffling. Alternatively spliced isoforms of IRSp53 exist. IRSp53 has been implicated in several psychiatric disorders, including autism spectrum disorders (ASDs), schizophrenia, and attention deficit/hyperactivity disorder (ADHD) (PMID: 26275848).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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